RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs.

@article{Tijsterman2002RNAHM,
  title={RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs.},
  author={Marcel Tijsterman and Ren{\'e} F Ketting and Kristy L. Okihara and Titia Sijen and Ronald H. A. Plasterk},
  journal={Science},
  year={2002},
  volume={295 5555},
  pages={694-7}
}
Posttranscriptional gene silencing in Caenorhabditis elegans results from exposure to double-stranded RNA (dsRNA), a phenomenon designated as RNA interference (RNAi), or from co-suppression, in which transgenic DNA leads to silencing of both the transgene and the endogenous gene. Here we show that single-stranded RNA oligomers of antisense polarity can also be potent inducers of gene silencing. As is the case for co-suppression, antisense RNAs act independently of the RNAi genes rde-1 and rde-4… CONTINUE READING
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