RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.

@article{Seo2015RNAHH,
  title={RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.},
  author={Mihwa Seo and Keunhee Seo and Wooseon Hwang and Hee Jung Koo and Jeong-Hoon Hahm and Jae-Seong Yang and Seong Kyu Han and Daehee Hwang and Sanguk Kim and Sungha Jang and Yoontae Lee and Hong Gil Nam and Seung-Jae V Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 31},
  pages={
          E4246-55
        }
}
The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the lifespan of Caenorhabditis elegans. In particular, we show that a DEAD-box RNA… CONTINUE READING

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