RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.

@article{Saporita2011RNAHD,
  title={RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.},
  author={Anthony J. Saporita and Hsiang-Chun Chang and Crystal L. Winkeler and Anthony J. Apicelli and Raleigh D. Kladney and Jianbo Wang and Raymond R. Townsend and Loren Scott Michel and Jason David Weber},
  journal={Cancer research},
  year={2011},
  volume={71 21},
  pages={
          6708-17
        }
}
The p19ARF tumor suppressor limits ribosome biogenesis and responds to hyperproliferative signals to activate the p53 checkpoint response. Although its activation of p53 has been well characterized, the role of ARF in restraining nucleolar ribosome production is poorly understood. Here we report the use of a mass spectroscopic analysis to identify protein changes within the nucleoli of Arf-deficient mouse cells. Through this approach, we discovered that ARF limited the nucleolar localization of… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…