RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans

@article{Walstrom2005RNAHA,
  title={RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans},
  author={Katherine M. Walstrom and Deborah E Schmidt and Christopher J. Bean and William G. Kelly},
  journal={Mechanisms of Development},
  year={2005},
  volume={122},
  pages={707-720}
}
RNA helicase A (RHA) is a multifunctional protein with established roles in chromatin regulation. The protein is conserved in worms, Drosophila, and mammals, but its role in worms has not been previously studied. We found that a deletion mutant lacking rha-1 has a temperature-sensitive defect in germline transcriptional silencing, consistent with RHA-1 having a function in transcription regulation. Transcriptional desilencing in these rha-1(tm329) mutants was associated with a loss of lysine 9… CONTINUE READING

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