RNA-guided genetic silencing systems in bacteria and archaea

@article{Wiedenheft2012RNAguidedGS,
  title={RNA-guided genetic silencing systems in bacteria and archaea},
  author={Blake Wiedenheft and Samuel H. Sternberg and Jennifer A. Doudna},
  journal={Nature},
  year={2012},
  volume={482},
  pages={331-338}
}
  • Blake Wiedenheft, Samuel H. Sternberg, Jennifer A. Doudna
  • Published 2012
  • Biology, Medicine
  • Nature
  • Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNA interference (RNAi) pathways in eukaryotes, CRISPR-mediated immune systems rely on small RNAs for sequence-specific detection and silencing of foreign nucleic acids, including viruses and plasmids. However, the mechanism of RNA-based bacterial immunity is distinct from RNAi. Understanding how small… CONTINUE READING

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