RNA-guided assembly of Rev-RRE nuclear export complexes

@inproceedings{Bai2014RNAguidedAO,
  title={RNA-guided assembly of Rev-RRE nuclear export complexes},
  author={Yun Bai and Akshay Tambe and Kaihong Zhou and Jennifer A. Doudna},
  booktitle={eLife},
  year={2014}
}
HIV replication requires nuclear export of unspliced and singly spliced viral transcripts. Although a unique RNA structure has been proposed for the Rev-response element (RRE) responsible for viral mRNA export, how it recruits multiple HIV Rev proteins to form an export complex has been unclear. We show here that initial binding of Rev to the RRE triggers RNA tertiary structural changes, enabling further Rev binding and the rapid formation of a viral export complex. Analysis of the Rev-RRE… CONTINUE READING
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