RNA folding pathways in stop motion

  title={RNA folding pathways in stop motion},
  author={Sandro Bottaro and Alejandro Gil-Ley and Giovanni Bussi},
  journal={Nucleic Acids Research},
  pages={5883 - 5891}
We introduce a method for predicting RNA folding pathways, with an application to the most important RNA tetraloops. The method is based on the idea that ensembles of three-dimensional fragments extracted from high-resolution crystal structures are heterogeneous enough to describe metastable as well as intermediate states. These ensembles are first validated by performing a quantitative comparison against available solution nuclear magnetic resonance (NMR) data of a set of RNA tetranucleotides… 

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