RNA folding causes secondary structure rearrangement.

  title={RNA folding causes secondary structure rearrangement.},
  author={Michael M. A. Wu and Ignacio Tinoco},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 20},
The secondary structure of the P5abc subdomain (a 56-nt RNA) of the Tetrahymena thermophila group I intron ribozyme has been determined by NMR. Its base pairing in aqueous solution in the absence of magnesium ions is significantly different from the RNA in a crystal but is consistent with thermodynamic predictions. On addition of magnesium ions, the RNA folds into a tertiary structure with greatly changed base pairing consistent with the crystal structure: three Watson-Crick base pairs, three G… CONTINUE READING
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