Corpus ID: 1543749

RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.

@article{Burger2003RNAEO,
  title={RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.},
  author={Herman Burger and John A. Foekens and Maxime P. Look and Marion E. Meijer-van Gelder and Jan G. M. Klijn and Erik A. C. Wiemer and Gerrit Stoter and Kees Nooter},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 2},
  pages={
          827-36
        }
}
  • Herman Burger, John A. Foekens, +5 authors Kees Nooter
  • Published in
    Clinical cancer research : an…
    2003
  • Biology, Medicine
  • PURPOSE The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease. EXPERIMENTAL DESIGN We determined mRNA levels of BCRP, LRP, MRP1, MRP2, and MDR1 in 59 primary breast tumor specimens of patients who received chemotherapy as first-line systemic treatment after diagnosis of advanced disease. The relative expression levels were measured by quantitative… CONTINUE READING

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