RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis.

  title={RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis.},
  author={Tatsuyoshi Funasaka and Hiroshi Nakano and Yu Wu and Chieko Hashizume and Ling Gu and Takuro Nakamura and Wei Wang and Pengbo Zhou and Malcolm A. S. Moore and Hiroshi Sato and Richard W Wong},
  journal={Cell cycle},
  volume={10 9},
Chromosomal translocations involving chimeric fusions of the nucleoporin NUP98 protein have often been described in acute myelogenous leukemia (AML). All the fusion proteins have an identical NUP98 N terminus, which contains the GLEBS motif for interaction with the mRNA export factor RAE1 and FG repeats that associate with the transcription factors HDAC1 and p300. It is virtually unknown whether these interaction partners affect leukemogenesis. We previously showed that RAE1 depletion caused… CONTINUE READING
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