RNA editing regulates transposon-mediated heterochromatic gene silencing.

  title={RNA editing regulates transposon-mediated heterochromatic gene silencing.},
  author={Yiannis A. Savva and James E. C. Jepson and Y J Chang and Rachel Whitaker and Brian C. Jones and Georges C St Laurent and Michael R. Tackett and Philipp Kapranov and Nan Jiang and Guyu Du and Stephen L. Helfand and R A Reenan},
  journal={Nature communications},
Heterochromatin formation drives epigenetic mechanisms associated with silenced gene expression. Repressive heterochromatin is established through the RNA interference pathway, triggered by double-stranded RNAs (dsRNAs) that can be modified via RNA editing. However, the biological consequences of such modifications remain enigmatic. Here we show that RNA editing regulates heterochromatic gene silencing in Drosophila. We utilize the binding activity of an RNA-editing enzyme to visualize the in… CONTINUE READING
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