RNA editing in trypanosomes

  title={RNA editing in trypanosomes},
  author={R. Benne},
  journal={Molecular Biology Reports},
Guide RNAs are encoded in maxicircle and minicircle DNA of trypanosome mitochondria. They play a pivotal role in RNA editing, a process during which the nucleotide sequence of mitochondrial RNAs is altered by U-insertion and deletion. Guide RNAs vary in length from 35 to 78 nucleotides, which correlates with the variation in length of the three functionally important regions of which they are composed: (i) a 4–14 nucleotide ‘anchor’ sequence embedded in the 5′ region, which is complementary to… CONTINUE READING