RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

  title={RNA editing in brain controls a determinant of ion flow in glutamate-gated channels},
  author={Bernd Sommer and Martin K{\"o}hler and Rolf Sprengel and P. H. Seeburg},
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing.
Site-selective nuclear RNA editing controls the calcium permeability of AMPA receptor channels, and RNA editing at a second site is shown here to affect the kinetic aspects of these channels in rat brain.
Molecular biology of glutamate receptors
Extent of RNA editing of glutamate receptor subunit GluR5 in different brain regions of the rat
The extent of RNA editing of glutamate receptor subunits may play an important role in the control of calcium fluxes through non-N-methyl-D-aspartate receptor channels in different physiological and/or pathological states of the brain.
RNA editing of a human glutamate receptor subunit.
Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.
This work has shown that the post-transcriptional conversion of adenosine to inosine (A-to-I) by RNA editing can dramatically expand the diversity of the transcriptome to generate multiple, functionally distinct protein isoforms from a single genomic locus.
A-to-I RNA editing modulates the pharmacology of neuronal ion channels and receptors
This review summarizes that RNA editing of several neuronal receptors and channels does not only change protein function, but also the pharmacology and presumably the drug therapy in human diseases.


Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.
These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.
Structural determinants of ion flow through recombinant glutamate receptor channels
The properties of heteromeric wild-type and mutant GluRs revealed that the dominance of GluR-B is due to the arginine residue in the TM2 region, and the steady-state current-voltage relations of glutamate- and kainate-induced currents through homomeric channels fell into two classes.
Molecular cloning and functional expression of glutamate receptor subunit genes.
Three closely related genes, GluR1, GluR2, and GluR3, encode receptor subunits for the excitatory neurotransmitter glutamate. The proteins encoded by the individual genes form homomeric ion channels
Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA
The cloning and expression of a functional rat glutamate receptor subunit cDNA, GluR6, which has a very different pharmacology from that of the GluLl–GluR4 class and exhibits an outwardly rectifying current–voltage relationship.
A family of AMPA-selective glutamate receptors.
Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed
The Murine GABAA Receptor δ-Subunit Gene: Structure and Assignment to Human Chromosome 1
The murine chromosomal gene for the GABAA receptor delta subunit was isolated and characterized by high-resolution mapping and DNA sequencing and displays an intron pattern comparable, but not identical, to that seen in members of the nicotinic acetylcholine receptor family.