RNA editing in Trypanosoma brucei requires three different editosomes.

@article{Carnes2008RNAEI,
  title={RNA editing in Trypanosoma brucei requires three different editosomes.},
  author={Jason Carnes and James Raffaello Trotter and Adam Peltan and Michele Fleck and Kenneth D. Stuart},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 1},
  pages={122-30}
}
Trypanosoma brucei has three distinct approximately 20S editosomes that catalyze RNA editing by the insertion and deletion of uridylates. Editosomes with the KREN1 or KREN2 RNase III type endonucleases specifically cleave deletion and insertion editing site substrates, respectively. We report here that editosomes with KREPB2, which also has an RNase III motif, specifically cleave cytochrome oxidase II (COII) pre-mRNA insertion editing site substrates in vitro. Conditional repression and… CONTINUE READING

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The Architecture of Trypanosoma brucei editosomes.

Proceedings of the National Academy of Sciences of the United States of America • 2016

References

Publications referenced by this paper.
Showing 1-10 of 67 references

COII EDITING REQUIRES KREN3 ENDONUCLEASE 129 on F ebuary 23

J. R. Trotter, N. L. Ernst, J. Carnes, B. Panicucci, K. Stuart
A VOL • 2005
View 7 Excerpts
Highly Influenced

Differential expression of mitochondrial genes between life cycle stages of Trypanosoma brucei.

Proceedings of the National Academy of Sciences of the United States of America • 1985
View 4 Excerpts
Highly Influenced

RNA stemloops : to be or not to be cleaved by RNase III

H. D. Robertson
2007

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