RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance

@article{Jones2001RNAdirectedTG,
  title={RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance},
  author={Louise Jones and Frank Ratcliff and David C. Baulcombe},
  journal={Current Biology},
  year={2001},
  volume={11},
  pages={747-757}
}
BACKGROUND The association between DNA methylation and gene silencing has long been recognized; however, signals that initiate de novo methylation are largely unknown. In plants, recognition of RNAs that are inducers of posttranscriptional gene silencing (PTGS) can result in sequence-specific DNA methylation, and the aim of this work was to investigate whether heritable epigenetic changes can occur by this mechanism and if the Met1 methyltransferase is required. RESULTS RNA-directed DNA… CONTINUE READING

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