RNA-directed transcriptional gene silencing in mammals.

@article{Bayne2005RNAdirectedTG,
  title={RNA-directed transcriptional gene silencing in mammals.},
  author={Elizabeth H. Bayne and Robin C. Allshire},
  journal={Trends in genetics : TIG},
  year={2005},
  volume={21 7},
  pages={
          370-3
        }
}
RNA interference is a highly conserved pathway mediating sequence-specific RNA degradation. In plants, the short RNA intermediates of this pathway can also drive transcriptional silencing of target genes by DNA methylation. Until recently, there was no evidence that a similar pathway operated in mammals; two new studies suggest that small RNAs can direct DNA methylation and chromatin modification in human cells. Although further investigation is required to determine how widespread RNA-directed… CONTINUE READING

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