RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

@article{Deb2001RNAdependentPK,
  title={RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.},
  author={Amitabha Deb and Saikh Jaharul Haque and Torben S. Mogensen and Robert H. Silverman and Bryan Raymond George Williams},
  journal={Journal of immunology},
  year={2001},
  volume={166 10},
  pages={6170-80}
}
The IFN-inducible dsRNA-activated protein kinase PKR regulates protein synthesis through phosphorylation of eukaryotic initiation factor-2alpha. It also acts as a signal transducer for transcription factors NF-kappaB, IFN regulatory factor-1, and activating transcription factor-2. IFN-gamma, a pleiotropic cytokine, elicits gene expression by activating the… CONTINUE READING