RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors.

@article{Roy2008RNAdependentLR,
  title={RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors.},
  author={Herv{\'e} Roy and Michael Ibba},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 12},
  pages={4667-72}
}
Multiple peptide resistance (MprF) virulence factors control cellular permeability to cationic antibiotics by aminoacylating inner membrane lipids. It has been shown previously that one class of MprF can use Lys-tRNA(Lys) to modify phosphatidylglycerol (PG), but the mechanism of recognition and possible role of other MprFs are unknown. Here, we used an in vitro reconstituted lipid aminoacylation system to investigate the two phylogenetically distinct MprF paralogs (MprF1 and MprF2) found in the… CONTINUE READING

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