RNA-dependent RNA polymerases, viruses, and RNA silencing.

  title={RNA-dependent RNA polymerases, viruses, and RNA silencing.},
  author={Paul Ahlquist},
  volume={296 5571},
Most viruses have RNA genomes that are replicated and transcribed into messenger RNA by viral RNA-dependent RNA polymerases (RdRps), usually in concert with other viral and host factors. Many, if not most, eukaryotes also encode putative RdRps that have been implicated in sequence-specific, RNA-triggered gene silencing. Although the viral and cellular RdRps have no sequence homology, they share functional similarities such as copying messenger RNA templates and intercellular spread of the… CONTINUE READING