RNA decay machines: the exosome.

@article{Chlebowski2013RNADM,
  title={RNA decay machines: the exosome.},
  author={Aleksander Chlebowski and Michał Lubas and Torben Heick Jensen and Andrzej Dziembowski},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1829 6-7},
  pages={
          552-60
        }
}
The multisubunit RNA exosome complex is a major ribonuclease of eukaryotic cells that participates in the processing, quality control and degradation of virtually all classes of RNA in Eukaryota. All this is achieved by about a dozen proteins with only three ribonuclease activities between them. At first glance, the versatility of the pathways involving the exosome and the sheer multitude of its substrates are astounding. However, after fifteen years of research we have some understanding of… CONTINUE READING
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