RNA damage and surveillance under oxidative stress

  title={RNA damage and surveillance under oxidative stress},
  author={Zhongwei Li and Jinhua Wu and Christopher J. DeLeo},
  journal={IUBMB Life},
RNA damage has been recently reported to increase under oxidative stress and in patients with many degenerative diseases, which has drawn attention to the consequences of RNA oxidation at the molecular and cellular levels. Under similar conditions the levels of oxidative damage in RNA are usually higher than those in DNA, which may impair protein synthesis or other RNA function. Therefore, accumulation of RNA damage must be prevented and cells have developed specific mechanisms to remove… 

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