RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

@article{Tuorto2012RNACM,
  title={RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis},
  author={Francesca Tuorto and Reinhard Liebers and Tanja Musch and Matthias Sch{\"a}fer and Sarah Hofmann and Stefanie Kellner and Michaela Frye and Mark Helm and Georg Stoecklin and Frank Lyko},
  journal={Nature Structural &Molecular Biology},
  year={2012},
  volume={19},
  pages={900-905}
}
The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained obscure, particularly in mammals. We have now developed a mouse strain defective in cytosine-C5 tRNA methylation, by disrupting both the Dnmt2 and the NSun2 tRNA methyltransferases. Although the lack of either enzyme alone has no detectable effects on mouse viability, double mutants showed a synthetic lethal interaction, with an underdeveloped phenotype and impaired cellular differentiation. tRNA… CONTINUE READING

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