RNA-binding proteins: modular design for efficient function

  title={RNA-binding proteins: modular design for efficient function},
  author={Bradley M. Lunde and Claire Moore and Gabriele Varani},
  journal={Nature Reviews Molecular Cell Biology},
Many RNA-binding proteins have modular structures and are composed of multiple repeats of just a few basic domains that are arranged in various ways to satisfy their diverse functional requirements. Recent studies have investigated how different modules cooperate in regulating the RNA-binding specificity and the biological activity of these proteins. They have also investigated how multiple modules cooperate with enzymatic domains to regulate the catalytic activity of enzymes that act on RNA… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 125 references

Engineering RNA sequence specificity of Pumilio repeats.

Proceedings of the National Academy of Sciences of the United States of America • 2006

Mapping of the auto - inhibitory interactions of protein kinase R by nuclear magnetic resonance

S. Li
J . Mol . Biol . • 2006

Molecular basis for PKR activation by PACT or dsRNA

P. C. Bevilacqua, T. R. Cech
Proc . Natl Acad . Sci . USA • 2006

Molecular basis of RNA recognition and TAP binding by the SR proteins SRp 20 and 9 G 8

Y. Hargous
EMBO J . • 2006

Molecular basis of RNA recognition by the human alternative splicing factor Fox - 1

S. D. Auweter
EMBO J . • 2006

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