RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma.

@article{Jeng2008RNAbindingPI,
  title={RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma.},
  author={Yung-Ming Jeng and Cheng-Chi Chang and Fu-chang Hu and H. Y. E. Chou and H Kao and Ting-Huang Wang and H Hsu},
  journal={Hepatology},
  year={2008},
  volume={48 4},
  pages={1118-27}
}
UNLABELLED Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an RNA-binding protein expressed in embryonic tissues and multiple cancers. To investigate the role of IMP3 in hepatocellular carcinoma (HCC), its protein expression in the surgically resected unifocal tumors of 377 HCC patients (296 men and 81 women) with ages ranging from 7 to 88 years (mean, 55.49 years) was analyzed by immunohistochemistry. IMP3 was expressed in 255 (67.6%) of 377 resected unifocal primary HCCs. IMP3… CONTINUE READING
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