RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.

@article{Tarling2017RNAbindingPZ,
  title={RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.},
  author={Elizabeth J Tarling and Bethan L Clifford and Joan P Cheng and Pauline Morand and Angela Cheng and Ellen Lester and Tamer Sallam and Martin Turner and Thomas Quad de Aguiar Vallim},
  journal={The Journal of clinical investigation},
  year={2017},
  volume={127 10},
  pages={
          3741-3754
        }
}
Bile acids function not only as detergents that facilitate lipid absorption but also as signaling molecules that activate the nuclear receptor farnesoid X receptor (FXR). FXR agonists are currently being evaluated as therapeutic agents for a number of hepatic diseases due to their lipid-lowering and antiinflammatory properties. FXR is also essential for maintaining bile acid homeostasis and prevents the accumulation of bile acids. Elevated bile acids activate FXR, which in turn switches off… CONTINUE READING
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