RNA-binding protein Sam68 controls synapse number and local β-actin mRNA metabolism in dendrites

  title={RNA-binding protein Sam68 controls synapse number and local $\beta$-actin mRNA metabolism in dendrites},
  author={Matthew E. Klein and Thomas J. Younts and Pablo E. Castillo and Bryen A Jordan},
  journal={Proceedings of the National Academy of Sciences},
  pages={3125 - 3130}
Proper synaptic function requires the spatial and temporal compartmentalization of RNA metabolism via transacting RNA-binding proteins (RBPs). Loss of RBP activity leads to abnormal posttranscriptional regulation and results in diverse neurological disorders with underlying deficits in synaptic morphology and transmission. Functional loss of the 68-kDa RBP Src associated in mitosis (Sam68) is associated with the pathogenesis of the neurological disorder fragile X tremor/ataxia syndrome. Sam68… 

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