RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment.

@article{Yeh2008RNAbindingPH,
  title={RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment.},
  author={Chiu-Hung Yeh and L Hung and Chin - Ming Hsu and S Le and Pin-Tse Lee and Wan-Lin Liao and Yi-Tseng Lin and Wen-Chang Chang and Joseph T. Tseng},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 9},
  pages={
          3812-22
        }
}
Reduction in host-activated protein C levels and resultant microvascular thrombosis highlight the important functional role of protein C anticoagulant system in the pathogenesis of sepsis and septic shock. Thrombomodulin (TM) is a critical factor to activate protein C in mediating the anticoagulation and anti-inflammation effects. However, TM protein content is decreased in inflammation and sepsis, and the mechanism is still not well defined. In this report, we identified that the TM 5… CONTINUE READING