RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.

@article{Ihara2013RNABM,
  title={RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.},
  author={Ryoko Ihara and Koji Matsukawa and Yusei Nagata and Hayato Kunugi and Shoji Tsuji and Takahiro Chihara and Erina Kuranaga and Masayuki Miura and Tomoko Wakabayashi and Tadafumi Hashimoto and Takeshi Iwatsubo},
  journal={Human molecular genetics},
  year={2013},
  volume={22 22},
  pages={4474-84}
}
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive and selective loss of motor neurons. The discovery of mutations in the gene encoding an RNA-binding protein, TAR DNA-binding protein of 43 kD (TDP-43), in familial ALS, strongly implicated abnormalities in RNA processing in the pathogenesis of ALS, although the mechanisms whereby TDP-43 leads to neurodegeneration remain elusive. To clarify the mechanism of degeneration caused by TDP-43, we generated… CONTINUE READING
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