RNA-binding activity of translation initiation factor eIF4G1 from Saccharomyces cerevisiae.

@article{Berset2003RNAbindingAO,
  title={RNA-binding activity of translation initiation factor eIF4G1 from Saccharomyces cerevisiae.},
  author={Catherine Berset and Andreas Zurbriggen and Siamak Djafarzadeh and Michael Altmann and H. Trachsel},
  journal={RNA},
  year={2003},
  volume={9 7},
  pages={871-80}
}
We identified and mapped RNA-binding sites of yeast Saccharomyces cerevisiae translation initiation factor eIF4G1 and examined their importance for eIF4G1 function in vitro and in vivo. Yeast eIF4G1 binds to single-stranded RNA with three different sites, the regions of amino acids 1-82 (N terminus), 492-539 (middle), and 883-952 (C terminus). The middle and C-terminal RNA-binding sites represent RS (arginine and serine)-rich domains; the N-terminal site is asparagine-, glutamine- and glycine… CONTINUE READING

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