RNA aptamer-based electrochemical aptasensor for C-reactive protein detection using functionalized silica microspheres as immunoprobes.

@article{Wang2017RNAAE,
  title={RNA aptamer-based electrochemical aptasensor for C-reactive protein detection using functionalized silica microspheres as immunoprobes.},
  author={Junchun Wang and Jinjin Guo and Jinfeng Zhang and Wenjuan Zhang and Yuzhong Zhang},
  journal={Biosensors & bioelectronics},
  year={2017},
  volume={95},
  pages={100-105}
}
C-reactive protein (CRP) is a widely accepted biomarker of cardiovascular disease and inflammation. In this study, a RNA aptamer-based electrochemical sandwich type aptasensor for CRP detection was described using the functionalized silica microspheres as immunoprobes. Silica microspheres (Si MSs), which have good monodispersity and uniform shape, were firstly synthesized. The silica microspheres functionlized with gold nanoparticles (Au NPs) provided large surface area for immobilizing signal… CONTINUE READING
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