RNA and microRNAs in fragile X mental retardation

  title={RNA and microRNAs in fragile X mental retardation},
  author={Peng Jin and Reid S Alisch and Stephen T Warren},
  journal={Nature Cell Biology},
Fragile X syndrome is caused by the loss of an RNA-binding protein called FMRP (for fragile X mental retardation protein). FMRP seems to influence synaptic plasticity through its role in mRNA transport and translational regulation. Recent advances include the identification of mRNA ligands, FMRP-mediated mRNA transport and the neuronal consequence of FMRP deficiency. FMRP was also recently linked to the microRNA pathway. These advances provide mechanistic insight into this disorder, and into… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 82 references

Control of dendritic development by the Drosophila fragile X-related gene print rv028.indd

A Lee
Nature Publishing Group © • 2004

FMRP and IMP1 interact on mRNAs

O. Rackham, Brown, C. M. Visualization of RNA–protein interactions in li cells
EMBO J. 23, 3346–3355 • 2004

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