RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System

@inproceedings{Liu2017RNAAD,
  title={RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System},
  author={Tina Y Liu and Anthony T. Iavarone and Jennifer A. Doudna},
  booktitle={PloS one},
  year={2017}
}
CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are RNA-guided adaptive immunity pathways used by bacteria and archaea to defend against phages and plasmids. Type III-A systems use a multisubunit interference complex called Csm, containing Cas proteins and a CRISPR RNA (crRNA) to target cognate nucleic acids. The Csm complex is intriguing in that it mediates RNA-guided targeting of both RNA and transcriptionally active DNA, but the mechanism is… CONTINUE READING
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