RNA Signals Required for Replication of Hepatitis C Virus RNA

@inproceedings{Yi2003RNASR,
  title={RNA Signals Required for Replication of Hepatitis C Virus RNA},
  author={MinKyung Yi and Stanley M Lemon},
  year={2003}
}
We describe a mutational analysis of the 3 nontranslated RNA (3 NTR) signals required for replication of subgenomic hepatitis C virus (HCV) RNAs. A series of deletion mutants was constructed within the background of an HCV-N replicon that induces the expression of secreted alkaline phosphatase in order to examine the requirements for each of the three domains comprising the 3 NTR, namely, the highly conserved 3 terminal 98-nucleotide (nt) segment (3 X), an upstream poly(U)-poly(UC) [poly(U/UC… CONTINUE READING