RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity

@article{Bardsley2018RNASR,
  title={RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity},
  author={Emma N Bardsley and Harvey Davis and Olujimi A. Ajijola and Keith J Buckler and Jeffrey L. Ardell and Kalyanam Shivkumar and David J. Paterson},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
Cardiovascular disease is the most prevalent age-related illness worldwide, causing approximately 15 million deaths every year. Hypertension is central in determining cardiovascular risk and is a strong predictive indicator of morbidity and mortality; however, there remains an unmet clinical need for disease-modifying and prophylactic interventions. Enhanced sympathetic activity is a well-established contributor to the pathophysiology of hypertension, however the cellular and molecular changes… Expand
Transcriptional profiling of stellate ganglia from normotensive and spontaneously hypertensive rat strains
TLDR
RNA-sequencing was used to identify transcriptomal differences in the sympathetic stellate ganglia between 16-week-old normotensive Wistar rats and spontaneously hypertensive rats and identified lead transcripts as a priori targets for further investigation. Expand
Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats
TLDR
Several gene expression differences between male and female stellates are identified, including genes encoding important developmental factors, receptors and neuropeptides, and no statistically significant differences were identified between the sexes in cardiac tyrosine hydroxylase levels. Expand
Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia
TLDR
Evidence is demonstrated for a renin-angiotensin synthesis pathway within human and rat sympathetic stellate ganglia, where significant alterations were observed in the spontaneously hypertensive rat stellated ganglia compared with Wistar stellates. Expand
Neurocardiac regulation: from cardiac mechanisms to novel therapeutic approaches
TLDR
Some of the key cellular and molecular pathways that contribute to sympathetic overactivity in hypertension are addressed and their potential for therapeutic targeting is discussed. Expand
Neurotransmitter Switching Coupled to β-Adrenergic Signaling in Sympathetic Neurons in Prehypertensive States
TLDR
It is concluded that neurotransmitter switching resulting in enhanced epinephrine release, may provide presynaptic positive feedback on &bgr;-adrenoceptors to promote further release, that leads to greater postsynaptic excitability in disease, before increases in arterial blood pressure. Expand
The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies
TLDR
The authors discuss the neuroanatomical and neurophysiological basis for neuromodulation therapy, critically appraise the latest data on the clinical efficacy of this approach and highlight areas in the field of cardiac autonomic control that show the most promise for clinical translation. Expand
Effects of ticagrelor pretreatment on electrophysiological properties of stellate ganglion neurons following myocardial infarction
TLDR
The data suggest that ticagrelor exerts cardioprotective effects, potentially through modulating the activity of different ion channels in SG neurons following myocardial infarction in rabbits. Expand

References

SHOWING 1-10 OF 81 REFERENCES
Transcriptional profiling of stellate ganglia from normotensive and spontaneously hypertensive rat strains
TLDR
RNA-sequencing was used to identify transcriptomal differences in the sympathetic stellate ganglia between 16-week-old normotensive Wistar rats and spontaneously hypertensive rats and identified lead transcripts as a priori targets for further investigation. Expand
Impaired cAMP-cGMP cross-talk during cardiac sympathetic dysautonomia
TLDR
It is reported that PGSNwhole-cell Ca2C currents of the pro-SHR are greater when compared to normotensive rats, and a novel link between impaired cyclic nucleotide signaling and increased N-type Ca 2C channel activity in prohypertension is demonstrated. Expand
Peripheral cardiac sympathetic hyperactivity in cardiovascular disease: role of neuropeptides.
  • J. Shanks, N. Herring
  • Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2013
TLDR
There is as a strong correlation between plasma NPY levels and coronary microvascular function in patients with ST-elevation myocardial infarction being treated with primary percutaneous coronary intervention and there is a direct action of the sympathetic cotransmitters neuropeptide Y and galanin on the ability of the vagus to release acetylcholine and control heart rate. Expand
Targeting cardiac sympatho-vagal imbalance using gene transfer of nitric oxide synthase.
TLDR
Novel techniques have been used to augment these signaling pathways experimentally in a targeted fashion to central autonomic nuclei, cardiac neurons, and myocytes using gene transfer of NO synthase. Expand
Ganglion-Specific Impairment of the Norepinephrine Transporter in the Hypertensive Rat
TLDR
Dysregulation of the norepinephrine transporter in the hypertensive rat is ganglion-specific, where NET impairment in the stellate neurons may contribute to the increased cardiac norpinephrine spillover seen in hypertension. Expand
Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons
TLDR
The data suggest that abnormally high levels of phosphodiesterase 2A may provide a brake against the inhibitory action of BNP on sympathetic transmission. Expand
Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States
TLDR
Dysregulation of cyclic-nucleotide (CN)-linked neuronal Ca2+ channel activity is identified that could provide the trigger for the enhanced sympathetic neurotransmission observed in the prohypertensive state and provides evidence that increasing cGMP rescues the channel phenotype and restores ion channel activity to levels seen in normal neurons. Expand
Autonomic imbalance, hypertension, and cardiovascular risk.
Essential hypertension conveys an increased risk of cardiovascular morbidity and mortality. The common finding of an autonomic imbalance in these patients contributes not only to the etiology ofExpand
Sympathetic nervous activation in essential hypertension: commonly neglected as a therapeutic target, usually ignored as a drug side effect.
TLDR
The recently published analysis of coronary heart disease clinical presentations in German nationals in Munich during the 2006 Federation Internationale de Football Association World Cup provides a telling example in demonstrating a dose-response relationship of the level of acute mental stress to cardiac events. Expand
Targeted Neuronal Nitric Oxide Synthase Transgene Delivery Into Stellate Neurons Reverses Impaired Intracellular Calcium Transients in Prehypertensive Rats
TLDR
Artificial upregulation of stellate sympathetic nNOS via targeted gene transfer can directly attenuate intracellular Ca2+ and may provide a novel method for decreasing enhanced cardiac sympathetic neurotransmission. Expand
...
1
2
3
4
5
...