RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain.

@article{Farris2014RNASeqRN,
  title={RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain.},
  author={Sean P Farris and R Dayne Mayfield},
  journal={International review of neurobiology},
  year={2014},
  volume={116},
  pages={275-300}
}
DNA microarrays have been used for over a decade to profile gene expression on a genomic scale. While this technology has advanced our understanding of complex cellular function, the reliance of microarrays on hybridization kinetics results in several technical limitations. For example, knowledge of the sequences being probed is required, distinguishing similar sequences is difficult because of cross-hybridization, and the relatively narrow dynamic range of the signal limits sensitivity… CONTINUE READING