RNA-Seq provides new insights in the transcriptome responses induced by the carcinogen benzo[a]pyrene.

@article{Delft2012RNASeqPN,
  title={RNA-Seq provides new insights in the transcriptome responses induced by the carcinogen benzo[a]pyrene.},
  author={Joost H M van Delft and Stan Gaj and Matthias Lienhard and Marcus W. Albrecht and Alexander A Kirpiy and Karen J. J. Brauers and Sandra M. H. Claessen and Daneida Liz{\'a}rraga and Hans Lehrach and Ralf Herwig and Jos Kleinjans},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={130 2},
  pages={427-39}
}
Whole-genome transcriptome measurements are pivotal for characterizing molecular mechanisms of chemicals and predicting toxic classes, such as genotoxicity and carcinogenicity, from in vitro and in vivo assays. In recent years, deep sequencing technologies have been developed that hold the promise of measuring the transcriptome in a more complete and unbiased manner than DNA microarrays. Here, we applied this RNA-seq technology for the characterization of the transcriptomic responses in HepG2… CONTINUE READING

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