RNA-Seq Profiling of Spinal Cord Motor Neurons from a Presymptomatic SOD1 ALS Mouse

@inproceedings{Bandyopadhyay2013RNASeqPO,
  title={RNA-Seq Profiling of Spinal Cord Motor Neurons from a Presymptomatic SOD1 ALS Mouse},
  author={Urmi Bandyopadhyay and Justin Cotney and M{\'a}ria Nagy and Sunghee Oh and Jing Leng and Milind Mahajan and Shrikant Mane and Wayne Fenton and James P Noonan and Arthur L Horwich},
  booktitle={PloS one},
  year={2013}
}
Mechanisms involved with degeneration of motor neurons in amyotrophic lateral sclerosis (ALS; Lou Gehrig's Disease) are poorly understood, but genetically inherited forms, comprising ~10% of the cases, are potentially informative. Recent observations that several inherited forms of ALS involve the RNA binding proteins TDP43 and FUS raise the question as to whether RNA metabolism is generally disturbed in ALS. Here we conduct whole transcriptome profiling of motor neurons from a mouse strain… CONTINUE READING
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