RNA-Seq Analysis of Microglia Reveals Time-Dependent Activation of Specific Genetic Programs following Spinal Cord Injury

@inproceedings{Noristani2017RNASeqAO,
  title={RNA-Seq Analysis of Microglia Reveals Time-Dependent Activation of Specific Genetic Programs following Spinal Cord Injury},
  author={Harun Najib Noristani and Yannick Nicolas Gerber and Jean-Charles Sabourin and Marine Le Corre and Nicolas Lonjon and Nadine Mestre-Franc{\'e}s and H{\'e}l{\`e}ne Hirbec and Florence E Perrin},
  booktitle={Front. Mol. Neurosci.},
  year={2017}
}
Neurons have inherent competence to regrow following injury, although not spontaneously. Spinal cord injury (SCI) induces a pronounced neuroinflammation driven by resident microglia and infiltrating peripheral macrophages. Microglia are the first reactive glial population after SCI and participate in recruitment of monocyte-derived macrophages to the lesion site. Both positive and negative influence of microglia and macrophages on axonal regeneration had been reported after SCI, raising the… CONTINUE READING
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