RNA Polymerase II Subunits Link Transcription and mRNA Decay to Translation

@article{HarelSharvit2010RNAPI,
  title={RNA Polymerase II Subunits Link Transcription and mRNA Decay to Translation},
  author={Liat Harel-Sharvit and Naama Eldad and Gal Haimovich and Oren Barkai and Lea Duek and Mordechai Choder},
  journal={Cell},
  year={2010},
  volume={143},
  pages={552-563}
}
Little is known about crosstalk between the eukaryotic transcription and translation machineries that operate in different cell compartments. The yeast proteins Rpb4p and Rpb7p represent one such link as they form a heterodimer that shuttles between the nucleus, where it functions in transcription, and the cytoplasm, where it functions in the major mRNA decay pathways. Here we show that the Rpb4/7 heterodimer interacts physically and functionally with components of the translation initiation… CONTINUE READING