RNA Polymerase I Propagates Unidirectional Spreading of rDNA Silent Chromatin

@article{Buck2002RNAPI,
  title={RNA Polymerase I Propagates Unidirectional Spreading of rDNA Silent Chromatin},
  author={Stephen W. Buck and Joseph J. Sandmeier and Jeffrey S Smith},
  journal={Cell},
  year={2002},
  volume={111},
  pages={1003-1014}
}
The ribosomal DNA (rDNA) tandem array in Saccharomyces cerevisiae induces transcriptional silencing of RNA polymerase II-transcribed genes. This SIR2-dependent form of repression (rDNA silencing) also functions to limit rDNA recombination and is involved in life span control. In this report, we demonstrate that rDNA silencing spreads into the centromere-proximal unique sequence located downstream of RNA polymerase I (Pol I) transcription, but fails to enter the upstream telomere-proximal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat.

Proceedings of the National Academy of Sciences of the United States of America • 2013

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast.

Genes & development • 1997
View 6 Excerpts
Highly Influenced

Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Nucleic acids research • 2002
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…