RNA Polymerase I Propagates Unidirectional Spreading of rDNA Silent Chromatin

  title={RNA Polymerase I Propagates Unidirectional Spreading of rDNA Silent Chromatin},
  author={Stephen W. Buck and Joseph J. Sandmeier and Jeffrey S Smith},
The ribosomal DNA (rDNA) tandem array in Saccharomyces cerevisiae induces transcriptional silencing of RNA polymerase II-transcribed genes. This SIR2-dependent form of repression (rDNA silencing) also functions to limit rDNA recombination and is involved in life span control. In this report, we demonstrate that rDNA silencing spreads into the centromere-proximal unique sequence located downstream of RNA polymerase I (Pol I) transcription, but fails to enter the upstream telomere-proximal… CONTINUE READING


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