RNA Interference Targeting p110β Reduces Tumor Necrosis Factor-Alpha Production in Cellular Response to Wear Particles In vitro and Osteolysis In vivo

@article{Huang2013RNAIT,
  title={RNA Interference Targeting p110β Reduces Tumor Necrosis Factor-Alpha Production in Cellular Response to Wear Particles In vitro and Osteolysis In vivo},
  author={Jianbin Huang and Yue Ding and Dong-sheng Huang and Wei-ke Zeng and Zhi-ping Guan and Mei Zhang},
  journal={Inflammation},
  year={2013},
  volume={36},
  pages={1041-1054}
}
Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of p110β-targeted small interfering RNA (siRNA) and lentivirus on particle-induced inflammatory cytokine expression in the murine macrophage cell line, RAW264.7. siRNA- and lentivirus-targeting p110β were transfected and infected prior to particle stimulation, respectively. Ceramic and… CONTINUE READING
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