RNA Interference (RNAi) Screening in Drosophila

@article{Heigwer2018RNAI,
  title={RNA Interference (RNAi) Screening in Drosophila},
  author={Florian Heigwer and Fillip Port and Michael Boutros},
  journal={Genetics},
  year={2018},
  volume={208},
  pages={853 - 874}
}
In the last decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided degradation of messenger RNA transcripts, has had an important impact on identifying and characterizing gene function. First discovered in Caenorhabditis elegans, RNAi can be used to silence the expression of genes through introduction of exogenous double-stranded RNA into cells. In Drosophila, RNAi has been applied in cultured cells or in vivo to perturb the function of single genes or to systematically… 

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