RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells

Abstract

The RNA exosome complex targets AU-rich element (ARE)-containing mRNAs in eukaryotic cells. We identified a transcription factor, ZSCAN10, which binds to the promoters of multiple RNA exosome complex subunits in pluripotent stem cells to maintain subunit gene expression. We discovered that induced pluripotent stem cell clones generated from aged tissue… (More)
DOI: 10.1016/j.stemcr.2017.08.024

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