RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing

@article{Ahlquist2002RNADependentRP,
  title={RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing},
  author={Paul Ahlquist},
  journal={Science},
  year={2002},
  volume={296},
  pages={1270 - 1273}
}
Most viruses have RNA genomes that are replicated and transcribed into messenger RNA by viral RNA–dependent RNA polymerases (RdRps), usually in concert with other viral and host factors. Many, if not most, eukaryotes also encode putative RdRps that have been implicated in sequence-specific, RNA-triggered gene silencing. Although the viral and cellular RdRps have no sequence homology, they share functional similarities such as copying messenger RNA templates and intercellular spread of the… 
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