RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing
@article{Ahlquist2002RNADependentRP, title={RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing}, author={P. Ahlquist}, journal={Science}, year={2002}, volume={296}, pages={1270 - 1273} }
Most viruses have RNA genomes that are replicated and transcribed into messenger RNA by viral RNA–dependent RNA polymerases (RdRps), usually in concert with other viral and host factors. Many, if not most, eukaryotes also encode putative RdRps that have been implicated in sequence-specific, RNA-triggered gene silencing. Although the viral and cellular RdRps have no sequence homology, they share functional similarities such as copying messenger RNA templates and intercellular spread of the… Expand
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References
SHOWING 1-10 OF 66 REFERENCES
Cellular factors in the transcription and replication of viral RNA genomes: a parallel to DNA-dependent RNA transcription.
- Biology, Medicine
- Virology
- 1998
- 287
Switch from translation to RNA replication in a positive-stranded RNA virus.
- Biology, Medicine
- Genes & development
- 1998
- 502
- PDF
Host RNA Polymerase Requirements for Transcription of the Human Hepatitis Delta Virus Genome
- Biology, Medicine
- Journal of Virology
- 2001
- 72
- PDF
An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus
- Biology, Medicine
- Cell
- 2000
- 1,052
- PDF
RNA Helicase MUT-14-Dependent Gene Silencing Triggered in C. elegans by Short Antisense RNAs
- Medicine, Biology
- Science
- 2002
- 172
Rolling Circle Replication of Hepatitis Delta Virus RNA Is Carried Out by Two Different Cellular RNA Polymerases
- Biology, Medicine
- Journal of Virology
- 2002
- 105
- PDF