RNA Degradation by the Exosome Is Promoted by a Nuclear Polyadenylation Complex

@article{LaCava2005RNADB,
  title={RNA Degradation by the Exosome Is Promoted by a Nuclear Polyadenylation Complex},
  author={John LaCava and J. Houseley and C. Saveanu and E. Petfalski and E. Thompson and A. Jacquier and D. Tollervey},
  journal={Cell},
  year={2005},
  volume={121},
  pages={713-724}
}
The exosome complex of 3'-5' exonucleases participates in RNA maturation and quality control and can rapidly degrade RNA-protein complexes in vivo. However, the purified exosome showed weak in vitro activity, indicating that rapid RNA degradation requires activating cofactors. This work identifies a nuclear polyadenylation complex containing a known exosome cofactor, the RNA helicase Mtr4p; a poly(A) polymerase, Trf4p; and a zinc knuckle protein, Air2p. In vitro, the Trf4p/Air2p/Mtr4p… Expand
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Yeast Trf5p is a nuclear poly(A) polymerase
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