RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo.

@article{Wesselhoeft2019RNACD,
  title={RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo.},
  author={R Alexander Wesselhoeft and Piotr Stanislaw Kowalski and Frances C Parker-Hale and Yuxuan Huang and Namita Bisaria and Daniel G Anderson},
  journal={Molecular cell},
  year={2019},
  volume={74 3},
  pages={
          508-520.e4
        }
}
Circular RNAs (circRNAs) are a class of single-stranded RNAs with a contiguous structure that have enhanced stability and a lack of end motifs necessary for interaction with various cellular proteins. Here, we show that unmodified exogenous circRNA is able to bypass cellular RNA sensors and thereby avoid provoking an immune response in RIG-I and Toll-like receptor (TLR) competent cells and in mice. The immunogenicity and protein expression stability of circRNA preparations are found to be… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-2 OF 2 CITATIONS