RNA-Catalyzed RNA Polymerization: Accurate and General RNA-Templated Primer Extension

@article{Johnston2001RNACatalyzedRP,
  title={RNA-Catalyzed RNA Polymerization: Accurate and General RNA-Templated Primer Extension},
  author={W. K. Johnston and P. Unrau and M. Lawrence and M. E. Glasner and D. Bartel},
  journal={Science},
  year={2001},
  volume={292},
  pages={1319 - 1325}
}
  • W. K. Johnston, P. Unrau, +2 authors D. Bartel
  • Published 2001
  • Biology, Medicine
  • Science
  • The RNA world hypothesis regarding the early evolution of life relies on the premise that some RNA sequences can catalyze RNA replication. In support of this conjecture, we describe here an RNA molecule that catalyzes the type of polymerization needed for RNA replication. The ribozyme uses nucleoside triphosphates and the coding information of an RNA template to extend an RNA primer by the successive addition of up to 14 nucleotides—more than a complete turn of an RNA helix. Its polymerization… CONTINUE READING

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