RNA Cargoes Associating with FMRP Reveal Deficits in Cellular Functioning in Fmr1 Null Mice

@article{Miyashiro2003RNACA,
  title={RNA Cargoes Associating with FMRP Reveal Deficits in Cellular Functioning in Fmr1 Null Mice},
  author={Kevin Y. Miyashiro and Andrea Beckel-Mitchener and T.Patrick Purk and Kevin G. Becker and Tanya Barret and Lei Liu and Salvatore Carbonetto and Ivan Jeanne Weiler and William T. Greenough and James Eberwine},
  journal={Neuron},
  year={2003},
  volume={37},
  pages={417-431}
}
The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach, antibody-positioned RNA amplification (APRA), to identify the RNA cargoes associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex. Using APRA as a primary screen, putative FMRP RNA cargoes were assayed for their ability to bind directly to FMRP using traditional methods of assessing RNA-protein interactions… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 53 references

Corticosteroid actions in the hippocampus

V. Brown, K. Small, +3 authors S. T. Warren
2001
View 6 Excerpts
Highly Influenced

Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 6 Excerpts
Highly Influenced

RNAs that interact with the fragile X syndrome RNA binding protein FMRP.

Biochemical and biophysical research communications • 2000
View 4 Excerpts
Highly Influenced

Drosophila associated messenger ribonucleoprotein particle and identification fragile X protein , dFXR , regulates

F. R. Jackson, D. L. Nelson, B. A. Hassan
NEURONAL • 2002

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