RNA-Binding Proteins in the Control of LPS-Induced Macrophage Response

@inproceedings{Ostareck2019RNABindingPI,
  title={RNA-Binding Proteins in the Control of LPS-Induced Macrophage Response},
  author={Dirk H. Ostareck and Antje Ostareck-Lederer},
  booktitle={Front. Genet.},
  year={2019}
}
Innate immune response is triggered by pathogen components, like lipopolysaccharides (LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which involves mitogen activated protein kinases (MAPK) and nuclear factor kappa B (NFκB) in different pathway branches and ultimately induces inflammatory cytokine and chemokine expression, macrophage migration and phagocytosis. Timely gene transcription and post-transcriptional control of gene expression confer the adequate… CONTINUE READING
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