RNA-Binding Proteins Revisited - The Emerging Arabidopsis mRNA Interactome.

  title={RNA-Binding Proteins Revisited - The Emerging Arabidopsis mRNA Interactome.},
  author={Tino Koester and Claudius Marondedze and Katja M. Meyer and Dorothee Staiger},
  journal={Trends in plant science},
  volume={22 6},
RNA-protein interaction is an important checkpoint to tune gene expression at the RNA level. Global identification of proteins binding in vivo to mRNA has been possible through interactome capture - where proteins are fixed to target RNAs by UV crosslinking and purified through affinity capture of polyadenylated RNA. In Arabidopsis over 500 RNA-binding proteins (RBPs) enriched in UV-crosslinked samples have been identified. As in mammals and yeast, the mRNA interactomes came with a few… CONTINUE READING
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